physics.optics

arXiv:2501.00742v1 Announce Type: new Abstract: Partial differential equation (PDE) is an important math tool in science and engineering. This paper experimentally demonstrates an optical neural PDE solver by leveraging the back-propagation-free on-photonic-chip training of physics-informed neural networks.

arXiv:2412.14603v2 Announce Type: replace Abstract: Recently, the joint design of optical systems and downstream algorithms is showing significant potential. However, existing rays-described methods are limited to optimizing geometric degradation, making it difficult to fully represent the optical characteristics of complex, miniaturized lenses constrained by wavefront aberration or diffraction effects. In this work, we introduce a precise optical simulation model, and every operation in pipeline is differentiable. This model employs a novel initial value strategy to enhance the reliability of intersection calculation on high aspherics. Moreover, it utilizes a differential operator to reduce memory consumption during coherent point spread function calculations. To efficiently address various degradation, we design a joint optimization procedure that leverages field information. Guided by a general restoration network, the proposed method not only enhances the image quality, but also successively improves the optical performance across multiple lenses that are already in professional level. This joint optimization pipeline offers innovative insights into the practical design of sophisticated optical systems and post-processing algorithms. The source code will be made publicly available at https://github.com/Zrr-ZJU/Successive-optimization

arXiv:2412.00705v3 Announce Type: replace-cross Abstract: Photoacoustic imaging (PAI) suffers from inherent limitations that can degrade the quality of reconstructed results, such as noise, artifacts and incomplete data acquisition caused by sparse sampling or partial array detection. In this study, we proposed a new optimization method for both two-dimensional (2D) and three-dimensional (3D) PAI reconstruction results, called the regularized iteration method with shape prior. The shape prior is a probability matrix derived from the reconstruction results of multiple sets of random partial array signals in a computational imaging system using any reconstruction algorithm, such as Delay-and-Sum (DAS) and Back-Projection (BP). In the probability matrix, high-probability locations indicate high consistency among multiple reconstruction results at those positions, suggesting a high likelihood of representing the true imaging results. In contrast, low-probability locations indicate higher randomness, leaning more towards noise or artifacts. As a shape prior, this probability matrix guides the iteration and regularization of the entire array signal reconstruction results using the original reconstruction algorithm (the same algorithm for processing random partial array signals). The method takes advantage of the property that the similarity of the object to be imitated is higher than that of noise or artifact in the results reconstructed by multiple sets of random partial array signals of the entire imaging system. The probability matrix is taken as a prerequisite for improving the original reconstruction results, and the optimizer is used to further iterate the imaging results to remove noise and artifacts and improve the imaging fidelity. Especially in the case involving sparse view which brings more artifacts, the effect is remarkable. Simulation and real experiments have both demonstrated the superiority of this method.

arXiv:2412.09775v2 Announce Type: replace-cross Abstract: Correlative computational microscopy is accelerating the mapping of dynamic biological systems by integrating morphological and molecular measurements across spatial scales, from organelles to entire organisms. Visualization, measurement, and prediction of interactions among the components of biological systems can be accelerated by generalist computational imaging frameworks that relax the trade-offs imposed by multiplex dynamic imaging. This work reports a generalist framework for wave optical imaging of the architectural order (waveOrder) among biomolecules for encoding and decoding multiple specimen properties from a minimal set of acquired channels, with or without fluorescent labels. waveOrder expresses material properties in terms of elegant physically motivated basis vectors directly interpretable as phase, absorption, birefringence, diattenuation, and fluorophore density; and it expresses image data in terms of directly measurable Stokes parameters. We report a corresponding multi-channel reconstruction algorithm to recover specimen properties in multiple contrast modes. With this framework, we implement multiple 3D computational microscopy methods, including quantitative phase imaging, quantitative label-free imaging with phase and polarization, and fluorescence deconvolution imaging, across scales ranging from organelles to whole zebrafish. These advances are available via an extensible open-source computational imaging library, waveOrder, and a napari plugin, recOrder.

arXiv:2406.04388v2 Announce Type: replace-cross Abstract: Phase imaging is gaining importance due to its applications in fields like biomedical imaging and material characterization. In biomedical applications, it can provide quantitative information missing in label-free microscopy modalities. One of the most prominent methods in phase quantification is the Transport-of-Intensity Equation (TIE). TIE often requires multiple acquisitions at different defocus distances, which is not always feasible in a clinical setting. To address this issue, we propose to use chromatic aberrations to induce the required through-focus images with a single exposure, effectively generating a through-focus stack. Since the defocus distance induced by the aberrations is small, conventional TIE solvers are insufficient to address the resulting artifacts. We propose Zero-Mean Diffusion, a modified version of diffusion models designed for quantitative image prediction, and train it with synthetic data to ensure robust phase retrieval. Our contributions offer an alternative TIE approach that leverages chromatic aberrations, achieving accurate single-exposure phase measurement with white light and thus improving the efficiency of phase imaging. Moreover, we present a new class of diffusion models that are well-suited for quantitative data and have a sound theoretical basis. To validate our approach, we employ a widespread brightfield microscope equipped with a commercially available color camera. We apply our model to clinical microscopy of patients' urine, obtaining accurate phase measurements.